Manipulation of host response and trajectory of parasite survival: A damage-response framework perspective

Q: What does this research mean for the field?

The damage-response framework provides a theoretical perspective for understanding how parasites manipulate host immune responses to optimize their survival trajectory. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

Kritsada Pruksaphon; Nopawit Khamto; Artid Amsri; Maria de Lourdes Pereira; Joshua D. Nosanchuk; Sirida Youngchim

doi:10.1080/21505594.2026.2732345

September 14, 2026VirulenceOpen Access

Manipulation of host response and trajectory of parasite survival: A damage-response framework perspective

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Key Points

To evaluate how parasites alter host biological defenses and dictate survival trajectories through the lens of the damage-response framework.
Conceptual synthesis applying the damage-response framework to host-pathogen interactions and parasite persistence mechanisms.
Characterizes how pathogens actively manipulate host immune trajectories across a spectrum of tissue damage to support their own persistence.
Identifies that disease severity is governed by the combined magnitude of direct pathogen-mediated damage and host immunopathology.

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Implication

Theoretical analysis demonstrates host immune modulation and parasite survival dynamics in chronic infection, highlighting mechanisms shaping disease pathogenesis.

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Cite This Study

Pruksaphon et al. (2026) studied this question.

synapsesocial.com/papers/6aa912f99013453be30a0cef https://doi.org/10.1080/21505594.2026.2732345

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Manipulation of host response and trajectory of parasite survival: A damage-response framework perspective

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Manipulation of host response and trajectory of parasite survival: A damage-response framework perspective

Key Points

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