Key result
Pediatric rotavirus infection can spread via viremia to cause multi-organ replication, encephalopathy, and sudden death.
Provides evidence that rotavirus infection in children can extend beyond the intestinal tract through viremia.
Warrants vigilance for extraintestinal rotavirus complications in severe pediatric cases; leaves open incidence, mechanisms, and management implications.
A 2.5-year-old girl died suddenly during the course of rotavirus gastroenteritis. The autopsy showed encephalopathy with rotavirus systemic infection. Here, we provide evidence of rotavirus replication in multiple organs. Our findings clarify that rotavirus infection in children can extend beyond the intestinal tract through viremia.
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Nakano et al. (2011) studied this question. Rotavirus infection in children can extend beyond the intestinal tract via viremia, resulting in multi-organ viral replication, encephalopathy, and sudden death.
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