Key result
HCM patients with ICDs face ~3.4-fold higher mortality than the general population, driven by heart failure.
Why the study?
ICDs alter the natural history and causes of death in HCM patients, but detailed nationwide data on mortality causes were lacking.
What are the causes of death and mortality rates in hypertrophic cardiomyopathy patients with implantable defibrillators compared to the general population?
Observational (n=342)
Yes
What are the causes of death and mortality rates in hypertrophic cardiomyopathy patients with implantable defibrillators compared to the general population?
Effect estimate: SMR 3.4 (95% CI 2.4-4.5)
p-value: p=< 0.001
In HCM patients, ICDs effectively prevent premature arrhythmic death, shifting the primary cause of mortality to progressive heart failure, though overall mortality remains elevated compared to the general population.
No takes yet. Share an insight, caveat, or question.
Heart failure drives excess mortality in HCM patients despite ICDs; extends prior data by quantifying SMR versus general population and leaves optimal HF strategies open.
Magnusson et al. (2016) conducted an observational in Hypertrophic cardiomyopathy (n=342). Implantable defibrillators (ICDs) vs. Age and sex-matched Swedish general population was evaluated on All-cause mortality (SMR 3.4, 95% CI 2.4-4.5, p=< 0.001). Hypertrophic cardiomyopathy patients with implantable defibrillators had higher all-cause mortality than the general population (SMR 3.4; 95% CI 2.4-4.5; P<0.001), primarily due to heart failure.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: