Key result
Biphasic ICDs show lower defibrillation thresholds vs monophasic pulses and ~99% SCD survival.
Why the study?
Clinical experience with a new implantable cardioverter defibrillator capable of biphasic waveform pulses and enhanced data storage was needed to evaluate its effectiveness and defibrillation efficacy.
Does a new cardioverter defibrillator with biphasic waveforms and enhanced data storage effectively prevent arrhythmic death in patients with refractory ventricular tachyarrhythmias?
Population
162 patients with refractory ventricular tachyarrhythmias and/or aborted sudden cardiac death
Comparison
Biphasic waveform pulses vs monophasic waveform pulses
Design
Prospective multicenter cohort study
Follow-up
Mean 10.8 months
Authors
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Biphasic waveforms may lower defibrillation thresholds in ICDs; leaves open whether survival benefit holds versus monophasic devices in randomized cohorts.
Cohort (n=162)
Yes
Does a new cardioverter defibrillator with biphasic waveforms and enhanced data storage effectively prevent arrhythmic death in patients with refractory ventricular tachyarrhythmias?
The use of biphasic waveform pulses in implantable cardioverter defibrillators lowers defibrillation thresholds, facilitating high rates of nonthoracotomy implantation and effectively preventing sudden cardiac death.
J. Neuzner (1994) conducted a cohort in Refractory ventricular tachyarrhythmias and/or aborted sudden cardiac death (n=162). New cardioverter defibrillator capable of biphasic waveform pulse and enhanced data storage vs. Monophasic waveform (for defibrillation threshold testing) was evaluated on Cumulative survival from sudden cardiac death. A new cardioverter defibrillator with biphasic waveform pulses demonstrated lower defibrillation thresholds than monophasic pulses (10.2 J vs 17.4 J) and 98.8% survival from sudden cardiac death.
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