Key result
Treatment-naïve Hodgkin lymphoma is linked to higher mitochondrial ROS and increased myocardial FDG retention versus controls.
Why the study?
It was unknown whether redox stress seen in PBMCs of HL patients also occurs in NHL and whether oxidative damage affects tissues not directly involved in inflammation.
Case-Control (n=90)
No
Hodgkin lymphoma is associated with pronounced redox stress in PBMCs and increased myocardial FDG retention compared to non-Hodgkin lymphoma.
HL-specific PBMC and myocardial redox stress absent in NHL; leaves open its clinical monitoring or mechanistic role.
Background: Previous studies reported mitochondrial and endoplasmic reticulum redox stress in peripheral blood mononucleated cells (PBMCs) of treatment-naïve Hodgkin lymphoma (HL) patients. Here, we assessed whether this response also applies to non-HL (NHL) patients, and whether the oxidative damage is a selective feature of PBMCs or, rather, also affects tissues not directly involved in the inflammatory response. Methods: Isolated PBMCs of 28 HL, 9 diffuse large B cell lymphoma, 8 less aggressive-NHL, and 45 controls underwent flow cytometry to evaluate redox stress and uptake of the glucose analogue 2-NBDG. This analysis was complemented with the assay of malondialdehyde (MDA) levels and enzymatic activity of glucose-6P-dehydrogenase and hexose-6P-dehydrogenase (H6PD). In all lymphoma patients, 18F-fluoro-deoxyglucose uptake was estimated in the myocardium and skeletal muscles. Results: Mitochondrial reactive oxygen species generation and MDA levels were increased only in HL patients as well as H6PD activity and 2-NBDG uptake. Similarly, myocardial FDG retention was higher in HL than in other groups as opposed to a similar tracer uptake in the skeletal muscle. Conclusions: Redox stress of PBMCs is more pronounced in HL with respect to both NHL groups. This phenomenon is coherent with an increased activity of H6PD that also extends to the myocardium.
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Marini et al. (2023) conducted a case-control in Hodgkin and Non-Hodgkin Lymphoma (n=90). Hodgkin lymphoma vs. Non-Hodgkin lymphoma and healthy controls was evaluated on Mitochondrial reactive oxygen species generation, malondialdehyde levels, and myocardial FDG retention. Treatment-naïve Hodgkin lymphoma was associated with significantly higher mitochondrial reactive oxygen species generation and malondialdehyde levels in peripheral blood mononucleated cells, as well as increased myocardial FDG retention, compared to non-Hodgkin lymphoma and healthy controls.
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