Key result
Sonazoid-enhanced CDUS improves soft tissue tumor diagnostic sensitivity to ~87% versus unenhanced imaging.
Why the study?
Contrast-enhanced color Doppler ultrasonography using Sonazoid has been newly available and its ability to differentiate benign from malignant soft tissue tumors needed evaluation.
Does contrast-enhanced color Doppler ultrasonography with Sonazoid improve diagnostic accuracy for differentiating benign and malignant soft tissue tumors compared to unenhanced CDUS?
Population
180 patients with soft tissue tumors (118 benign, 62 malignant), mean age 58.1±20.0 years
Comparison
Contrast-enhanced CDUS using Sonazoid vs CDUS without Sonazoid
Design
Observational study
Authors
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May support noninvasive soft tissue tumor differentiation; hypothesis-generating and requires prospective validation before practice change.
Observational (n=180)
No
Does contrast-enhanced color Doppler ultrasonography with Sonazoid improve diagnostic accuracy for differentiating benign and malignant soft tissue tumors compared to unenhanced CDUS?
Absolute Event Rate: 74.3% vs 69.4%
Contrast-enhanced color Doppler ultrasonography with Sonazoid improves sensitivity and overall accuracy for detecting malignant potential in soft tissue tumors compared to unenhanced imaging.
Oebisu et al. (2014) conducted an observational in Soft tissue tumors (n=180). Contrast-enhanced color Doppler ultrasonography (Sonazoid) vs. Unenhanced color Doppler ultrasonography was evaluated on Diagnostic accuracy for differentiating benign and malignant soft tissue tumors. Contrast-enhanced color Doppler ultrasonography using Sonazoid increased diagnostic sensitivity to 87% and accuracy to 74% compared to 55% and 69% with unenhanced imaging for differentiating soft tissue tumors.
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