Key result
Acute hyperinsulinemia has no direct effect on plasma ANP or BNP levels despite volume increases.
Why the study?
The interrelationship between hyperinsulinemia and plasma natriuretic peptides was unclear, particularly the effects of acute hyperinsulinemia on ANP and BNP levels.
Does acute hyperinsulinemia directly affect plasma ANP and BNP concentrations in diabetic and normal subjects?
Comparison
Physiological and non-physiological hyperinsulinemia induced by glucose clamp, glucose challenge, and insulin challenge tests
Design
Physiological study using euglycemic–hyperinsulinemic glucose clamp and challenge tests
Follow-up
Acute
Authors
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Acute hyperinsulinemia does not directly alter ANP or BNP levels; leaves open whether sustained hyperinsulinemia affects natriuretic peptides in diabetes.
Does acute hyperinsulinemia directly affect plasma ANP and BNP concentrations in diabetic and normal subjects?
Acute hyperinsulinemia does not directly stimulate the release of atrial or brain natriuretic peptides in vivo.
Tanabe et al. (1995) studied Non-insulin-dependent diabetes mellitus and normal subjects (n=48). Acute hyperinsulinemia (via glucose clamp, glucose challenge, or insulin challenge) was evaluated on Plasma atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) concentrations. Acute hyperinsulinemia had no direct effect on plasma atrial or brain natriuretic peptide concentrations, despite significant increases in plasma insulin and volume during glucose challenges.
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