Key result
Gadobutrol triggers severe anaphylactic shock, cardiac arrest, and transient fibrinolytic DIC.
Why the study?
Gadolinium-based contrast agents have fewer severe acute adverse reactions than iodinated contrast agents, but serious anaphylaxis and subsequent complications can occur.
Case Report (n=1)
No
Gadolinium contrast agents like gadobutrol can cause severe anaphylactic reactions leading to cardiac arrest and transient hyperfibrinolytic DIC.
Answers are grounded in this paper and cite their sources.
Clinicians should remain vigilant for gadobutrol anaphylaxis with arrest and DIC; single case leaves open incidence and mechanisms.
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Morishima et al. (2023) conducted a case report in Anaphylactic shock and Disseminated Intravascular Coagulation (DIC) (n=1). Gadobutrol was evaluated on Development of anaphylactic shock, cardiac arrest, and DIC. Administration of the gadolinium-based contrast agent gadobutrol triggered severe anaphylactic shock and cardiac arrest within 10 minutes, followed by transient fibrinolytic DIC.
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