Key result
Microvascular dysfunction contributes to Chagas cardiomyopathy pathology alongside immune, neurogenic, and parasitic mechanisms.
Why the study?
The pathology and clinical course of myocardial involvement in chagasic cardiomyopathy require further explanation through microvascular, immunological, neurogenic, and parasitic mechanisms.
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This review highlights the microvascular hypothesis and other mechanisms underlying myocardial involvement in chagasic cardiomyopathy.
This review focuses on studies that support the microvascular hypothesis, as well as on immunological and neurogenic mechanisms, and the role of the parasite itself, to explain further the pathology and clinical course of myocardial involvement in chagasic cardiomyopathy. The salient features of coronary microcirculation and Chagas' disease are discussed.
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Ramos et al. (1999) studied this question.
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