Key result
Prediabetes in healthy obese adults is linked to ~350% higher hs-CRP and elevated fibrinogen.
Population
Healthy disease-free obese adults (n=35; 27 women, 8 men) from a weight loss study screening.
Design
Cross-sectional
Authors
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Prediabetes may heighten inflammation in obese adults without disease; cross-sectional data leave open causal links and clinical relevance.
Cross-Sectional (n=35)
No
Absolute Event Rate: 16.9% vs 3.7%
p-value: p=<0.0001
In otherwise healthy obese adults, the presence of prediabetes and prehypertension is associated with a significantly exacerbated systemic proinflammatory state.
Gupta et al. (2010) conducted a cross-sectional in Obesity (n=35). Prediabetes vs. Normoglycemia was evaluated on High sensitivity C-reactive protein (hs CRP) in mg/L (p=<0.0001). In otherwise healthy disease-free obese adults, prediabetes was associated with significantly higher levels of high sensitivity C-reactive protein (16.9 vs 3.7 mg/L, p<0.0001) and fibrinogen.
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