March 28, 2007The Journal of Clinical Endocrinology & Metabolism
Serum Insulin and Inflammatory Markers in Overweight Individuals with and without Dyslipidemia
Why the study?
Does dyslipidemia associate with worse metabolic and inflammatory profiles in overweight individuals?
Population
1,788 overweight individuals, comprising 715 dyslipidemic subjects and 1,073 normolipidemic controls.
Comparison
Dyslipidemia (observational exposure) vs Normolipidemia (controls)
Design
Case-control
Authors
Discussion
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Member takes
Implication
Dyslipidemia may flag heightened inflammation and insulin resistance in overweight adults; hypothesis-generating for targeted trials but should not yet alter practice.
Structured PICO
Does dyslipidemia associate with worse metabolic and inflammatory profiles in overweight individuals?
P
Population
1,788 overweight individuals (BMI > 25 kg/m2), comprising 715 dyslipidemic subjects (plasma triglyceride ≥ 75th percentile and HDL-C ≤ 25th percentile) and 1,073 normolipidemic controls (HDL-C > median and triglyceride < median).
I
Intervention
Dyslipidemia (observational exposure)
C
Comparator
Normolipidemia (controls)
O
Outcome
BMI, inflammatory markers, adipokines, blood pressure, and fasting plasma glucose and insulinsurrogate
Overweight individuals with dyslipidemia exhibit a generalized metabolic disorder with higher inflammation and insulin resistance, whereas those with normal lipids have a relatively benign metabolic profile.
Cite This Study
Barter et al. (2007) studied this question.