Key result
Obese subjects with normal triglycerides and low HDLc had a higher prevalence of elevated inflammatory cytokines and higher insulin resistance than those with normal HDLc.
Why the study?
What are the clinical and biochemical correlates of low HDLc in obese subjects with normal triglycerides?
Cross-Sectional (n=32)
What are the clinical and biochemical correlates of low HDLc in obese subjects with normal triglycerides?
Low HDLc in obesity without hypertriglyceridemia is associated with greater adiposity, insulin resistance, and elevated inflammatory cytokines.
Answers are grounded in this paper and cite their sources.
Low HDLc may flag higher inflammation and insulin resistance in obese patients with normal triglycerides; hypothesis-generating and needs longitudinal confirmation.
BACKGROUND: The cause of obesity-related low HDLc in the absence of hypertriglyceridemia is not known. SUBJECTS & METHODS: A total of 32 subjects with a body mass index (BMI)(kg/m(2)) greater than 30 and normal serum triglycerides (<150 mg/dl) were identified. RESULTS: People with low HDLc (n = 16) compared to those with normal HDLc (n = 16) had higher BMI (37.53 +/- 4.54 vs. 33.99 +/- 3.65 kg/m(2), p < 0.021), higher body fat weight (42.59 +/- 9.51 vs. 34.76 +/- 8.7 kg, p < 0.023), and higher insulin resistance index (3.75 +/- 2.51 vs. 1.95 +/- 1.10, p < 0.013). Seven subjects with low HDLc and none of those with normal HDLc, had elevated serum tumor necrosis factor alpha and/or interleukin-6 (p < 0.010). CONCLUSIONS: Low HDLc levels can occur in obesity independently of elevated serum triglycerides and may be secondary to elevated serum levels of inflammatory cytokines.
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Mooradian et al. (2006) conducted a cross-sectional in Obesity with normal serum triglycerides (n=32). Low HDLc vs. Normal HDLc was evaluated on Elevated serum tumor necrosis factor alpha and/or interleukin-6 (p=<0.010). Obese subjects with normal triglycerides and low HDLc had a higher prevalence of elevated inflammatory cytokines and higher insulin resistance than those with normal HDLc.
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