Montelukast sodium in cystic fibrosis

Many older patients with cystic fibrosis (CF) describe a component of their condition as “asthma” despite a lack of objective bronchial lability. We undertook a therapeutic trial of the leukotriene antagonist montelukast sodium in one such patient and observed a marked improvement in symptoms and peak expiratory flow rate (PEFR). Subsequently we performed an open label study in adult patients attending the Hull Adult Cystic Fibrosis Clinic. Eleven patients (eight male) of mean (range) age 25.9 (16–44) years with stable CF and no pulmonary infective exacerbations for at least four weeks entered a two week observation period during which they recorded a …