Cockroach-induced IL9, IL13, and IL31 expression and the development of allergic asthma in urban children

This is the authors' abstract. We don't add key points for this paper.

Type 2 (T2) immune responses are key risk factors in childhood for airway inflammation, bronchial hyperresponsiveness, and development of asthma. Developing sensitization to multiple allergens in the first few years of life is closely associated with the development of T2 inflammation and is especially important in light of its poor prognosis with respect to persistent asthma, increased exacerbations, and low lung function.1 Although some risk factors for the development of T2 inflammation and asthma are known, the longitudinal patterns of immune development that drive the imbalance toward a T2 immune response in humans are not fully understood.