Cohort study reveals an AKR1C polymorphism links to altered adipose AKR1C3 activity and increased metabolic risk in severe obesity, highlighting genetic drivers of lipid and insulin dysregulation.
rs28571858 has a minor allele frequency of 18.7% in a cohort of 2,776 residents of Quebec, Canada. rs28571858 is associated with adipose tissue AKR1C3 expression and activity in women. Minor allele homozygote carriers have increased total cholesterol, LDL-cholesterol, and indices of insulin resistance.
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Ostinelli et al. (2026) studied this question.
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