Key result
Higher total genotype score is linked to lower post-marathon creatine kinase response.
Why the study?
Does a specific polygenic profile associate with lower serum creatine kinase concentrations and reduced exertional muscle damage after a marathon?
Case-Control (n=67)
No
Does a specific polygenic profile associate with lower serum creatine kinase concentrations and reduced exertional muscle damage after a marathon?
Standardized Mean Difference: 0.58
Absolute Event Rate: 5.2% vs 4.4%
p-value: p=0.02
A more favorable polygenic profile is associated with lower serum creatine kinase concentrations and reduced exertional muscle damage after a marathon.
Supports polygenic profiling research for post-marathon muscle damage; hypothesis-generating and should not yet alter clinical recommendations.
PURPOSE: Exertional rhabdomyolysis can occur in individuals performing various types of exercise but it is unclear why some individuals develop this condition while others do not. Previous investigations have determined the role of several single nucleotide polymorphisms (SNPs) to explain inter-individual variability of serum creatine kinase (CK) concentrations after exertional muscle damage. However, there has been no research about the interrelationship among these SNPs. The purpose of this investigation was to analyze seven SNPs that are candidates for explaining individual variations of CK response after a marathon competition (ACE = 287bp Ins/Del, ACTN3 = p.R577X, CKMM = NcoI, IGF2 = C13790G, IL6 = 174G>C, MLCK = C37885A, TNFα = 308G>A). METHODS: Using Williams and Folland's model, we determined the total genotype score from the accumulated combination of these seven SNPs for marathoners with a low CK response (n = 36; serum CK <400 U·L-1) vs. marathoners with a high CK response (n = 31; serum CK ≥400 U·L-1). RESULTS: At the end of the race, low CK responders had lower serum CK (290±65 vs. 733±405 U·L-1; P<0.01) and myoglobin concentrations (443±328 vs. 1009±971 ng·mL-1, P<0.01) than high CK responders. Although the groups were similar in age, anthropometric characteristics, running experience and training habits, total genotype score was higher in low CK responders than in high CK responders (5.2±1.4 vs. 4.4±1.7 point, P = 0.02). CONCLUSION: Marathoners with a lower CK response after the race had a more favorable polygenic profile than runners with high serum CK concentrations. This might suggest a significant role of genetic polymorphisms in the levels of exertional muscle damage and rhabdomyolysis. Yet other SNPs, in addition to exercise training, might also play a role in the values of CK after damaging exercise.
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Coso et al. (2017) conducted a case-control in Exertional rhabdomyolysis (n=67). Low CK response (<400 U/L) vs. High CK response (≥400 U/L) was evaluated on Total genotype score (ES 0.58, p=0.02). Marathoners with a lower creatine kinase response after the race had a significantly higher total genotype score (5.2 vs. 4.4 points) than runners with high serum CK concentrations.
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