Why the study?
Recent evidence suggests the renin-angiotensin system impacts skeletal muscle wasting, but its genetic association with endurance exercise-induced inflammation, myocardial, and muscle injury was unclear.
Do ACE-related polymorphisms (AGT Met235Thr, ACE I/D, BDKRB2 -9/+9) affect inflammation and myocardial/muscle damage after a marathon race in male runners?
Population
Eighty-One Brazilian male runners completing the International Marathon of Sao Paulo
Comparison
AGT Met235Thr, ACE I/D, and BDKRB2 -9/+9 polymorphisms
Design
Observational cohort study
Follow-up
Fifteen days after race
Authors
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Associations may aid risk stratification in athletes; leaves open causality and need for prospective validation.
Do ACE-related polymorphisms (AGT Met235Thr, ACE I/D, BDKRB2 -9/+9) affect inflammation and myocardial/muscle damage after a marathon race in male runners?
Genetic polymorphisms in the renin-angiotensin and kallikrein-kinin systems (ACE II, AGT MM, BDKRB2 -9-9) may increase susceptibility to inflammation and myocardial/muscle injury following endurance exercise.
Sierra et al. (2019) studied this question.
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