Key result
Long-term thyroid extract and IV acetylcholine induce AF in ~81% of dogs.
Why the study?
Susceptibility to atrial fibrillation in thyrotoxic patients suggested a method to produce a similar condition in dogs for study.
Key points are not available for this paper at this time.
Population
Dogs fed long-term thyroid extract
Comparison
Thyroid extract feeding with vs without acetylcholine injection
Design
Experimental study
May induce AF in canine models; leaves open mechanistic relevance to human disease.
The observation of susceptibility to atrial fibrillation in the thyrotoxic patient suggests a method by which a similar condition may be produced in dogs. This has been accomplished by long-term thyroid extract feeding. Administration of acetylcholine to these dogs by intravenous injection has resulted in a high percentage (81 per cent) of atrial fibrillation.
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PHILLIP E. LEVEQUE (1956) studied this question. Long-term thyroid extract feeding combined with intravenous acetylcholine injection produced atrial fibrillation in 81% of dogs.
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