Molecular analysis reveals an aberrant kappa light chain transcript in MOPC-21-derived hybridomas, highlighting potential interference with productive antibody mRNA expression.
The V region sequence of a non-productive kappa transcript from two myeloma fusion partners has been determined. This transcript has an aberrant VJ recombination site resulting in a translation stop site at position 105. It is variably expressed in hybridomas made from all fusion partners derived from the original MOPC-21 tumor. The amount of this transcript may greatly exceed levels of the productive light chain mRNA.
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Carroll et al. (1988) studied this question.
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