Key result
RAG-1 and RAG-2 genes fail to activate immunoglobulin gene recombination without additional factors.
Population
Abelson virus-transformed pre-B-cell lines that fail to undergo VH-to-DJH joining at an appreciable frequency
Design
Preclinical
Authors
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RAG-1/2 transfer fails to rescue recombination in low-activity pre-B lines; leaves open identification of accessory factors regulating V(D)J recombination.
RAG-1 and RAG-2 are insufficient to direct all phases of immunoglobulin gene rearrangement in certain pre-B-cell lines, suggesting additional factors are required.
Wang et al. (1993) studied Abelson virus-transformed pre-B-cell lines. Introduction of RAG-1 and RAG-2 genes was evaluated on Immunoglobulin gene recombination. Introduction of RAG-1 and RAG-2 genes was not sufficient to activate immunoglobulin gene recombination in pre-B-cell lines, suggesting additional factors are required.
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