Key result
Local Intralipid and heparin coinfusion to raise fatty acids increases venoconstrictor response magnitude and duration.
Why the study?
Does local elevation of fatty acids enhance neurovascular reflex responses in healthy volunteers?
Population
9 healthy volunteers
Design
Other
Authors
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May link elevated fatty acids to heightened neurovascular tone in obese hypertension; hypothesis-generating and should not yet change practice.
Does local elevation of fatty acids enhance neurovascular reflex responses in healthy volunteers?
p-value: p=<0.005
Elevated nonesterified fatty acids enhance reflex vasoconstrictor responses via vascular alpha 1-adrenoceptors, suggesting a mechanism for increased neurovascular tone in obese hypertensive patients.
Stepniakowski et al. (1996) studied Healthy volunteers (n=9). Intralipid with heparin was evaluated on Magnitude and duration of the venoconstrictor response to thigh cuff inflation (p=<0.005). Local coinfusion of Intralipid with heparin to raise fatty acids significantly increased the magnitude and duration of the venoconstrictor response to thigh cuff inflation (P<0.005).
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