Why the study?
Does a 4-hour intravenous infusion of 20% Intralipid increase blood pressure and sympathetic nerve activity in lean healthy volunteers?
Population
17 lean healthy volunteers (10 male/7 female; mean age 22+/-1 years; BMI 23+/-1 kg/m2)
Comparison
4-hour intravenous infusion of 20% Intralipid vs 4-hour intravenous infusion of placebo
Design
RCT, randomized balanced order, single-blind
Follow-up
4 hours
Authors
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Acute Intralipid raises BP via sympathetic activation in healthy adults; confirms NEFA-driven central mechanism in hypertension.
Does a 4-hour intravenous infusion of 20% Intralipid increase blood pressure and sympathetic nerve activity in lean healthy volunteers?
Acute increases in non-esterified fatty acids raise blood pressure and systemic vascular resistance through central sympathetic activation in healthy humans.
Florian et al. (2009) studied this question.
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