What is the clinical evidence from this study?

Study design: Observational. Population: Inflammatory and HIV myopathies (n=22). Intervention: Inflammatory and HIV myopathies vs. Nonmyopathic controls. Primary outcome: TLR3 mRNA levels and expression.

What does this research mean for the field?

TLR3 is constitutively expressed in human skeletal muscle cells and shows elevated expression in muscle tissue from patients with inclusion body myositis and HIV-myopathies, where it mediates IL-8 release and susceptibility to NK-cell lysis. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 17, 2005The FASEB Journal

Expression of toll‐like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL‐8 release, and up‐regulation of NKG2D‐ligands

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Key result

Inclusion body myositis and HIV-myopathies exhibit elevated muscle TLR3 mRNA levels versus nonmyopathic controls.

n=22

Population

Cultured human myoblasts and rhabdomyosarcoma cells, and muscle biopsy specimens from 6 HIV patients with…

Comparison

Poly (I:C) and IFN-gamma challenge (in vitro) vs Unstimulated cells and nonmyopathic controls

Design

Preclinical

Authors

BSBettina SchreinerUniversity of Zurich JVJoachim G. VossNebraska Medical Center JWJörg WischhusenUniversity of Würzburg

Discussion

Member takes

Implication

May implicate TLR3 in myopathy inflammation; leaves open translation to clinical practice from animal data.

Study Design

Type

Observational (n=22)

Structured PICO

Population

22 muscle biopsy specimens from 6 HIV patients with IBM/PM, 7 cases of sporadic IBM, and 9 nonmyopathic controls.

Exposure

Poly (I:C) and IFN-gamma challenge (in vitro)

Comparator

Unstimulated cells (in vitro) and nonmyopathic controls (in vivo)

Outcome

TLR3 expression levels and localizationsurrogate

TLR3 plays an important role in the immunobiology of human muscle and is highly expressed in inflammatory and HIV myopathies, mediating inflammatory responses.

Cite This Study

Schreiner et al. (2005) conducted an observational in Inflammatory and HIV myopathies (n=22). Inflammatory and HIV myopathies vs. Nonmyopathic controls was evaluated on TLR3 mRNA levels and expression. TLR3 mRNA levels were elevated in muscle biopsy specimens from patients with inclusion body myositis and HIV-myopathies compared to nonmyopathic controls.

synapsesocial.com/papers/6aa930c11ed6af7fb80e0715 https://doi.org/10.1096/fj.05-4342fje

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Expression of toll‐like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL‐8 release, and up‐regulation of NKG2D‐ligands

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Expression of toll‐like receptors by human muscle cells in vitro and in vivo: TLR3 is highly expressed in inflammatory and HIV myopathies, mediates IL‐8 release, and up‐regulation of NKG2D‐ligands

Discussion

Member takes

Implication

Study Design

Structured PICO

Cite This Study

Also Consider

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