OBJECTIVE: To analyze infiltration patterns of IDH1 mutant diffuse gliomas into the brain by identification of single tumor cells applying an antibody specific to mutant IDH1 R132H protein. DESIGN: Immunohistochemical analysis. SETTING: University hospital. PATIENTS: Whole-brain and hemisphere sections of 4 patients diagnosed with diffuse glioma. RESULTS: Tumor cells were identified in areas that appeared inconspicuous macroscopically and at histological analysis with respect to cellularity, cellular pleomorphism, or mitotic activity in all cases. CONCLUSION: Detection of single tumor cells throughout the brain demonstrates diffuse glioma to represent systemic brain disease.
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