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Serum neutralizing antibodies rapidly appear after SARS-CoV-2 infection 1 and vaccination 2 and are maintained for several months.3,4 The emergence of SARS-CoV-2 variants has raised concerns about the breadth of neutralizingantibody responses.We compared the neutralizing-antibody response to 4 variants in infected and vaccinated individuals to determine how mutations within the spike protein are associated with virus neutralization.
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Edara et al. (2021) studied this question.
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