Key result
Anesthetic drugs emerge as a potential cause of neurodevelopmental impairment in infants with CHD.
Why the study?
There is important neurological morbidity in children with congenital heart disease, with multifactorial etiology including potential anesthetic neurotoxicity in neonates and infants.
This review highlights the multifactorial causes of neurodevelopmental impairment in children with congenital heart disease, emphasizing the potential neurotoxic role of anesthetic agents in neonates and infants.
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May support minimizing anesthetic exposure during neonatal CHD repair; hypothesis-generating for prospective neuroprotection trials.
Helen Holtby (2012) conducted a review in Congenital heart disease. Anesthetic drugs was evaluated on Neurodevelopmental impairment. Neurodevelopmental impairment in children with congenital heart disease is multifactorial, with anesthetic drugs emerging as a potential cause of central nervous system morbidity in neonates and infants.
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