Key result
Supplemental sodium acetate improves CAI-induced malaise and fatigue in ~36% more patients than placebo.
Why the study?
The effect of supplemental sodium acetate on carbonic anhydrase inhibitor-induced side effects such as malaise and fatigue was uncertain.
Does supplemental sodium acetate improve carbonic anhydrase inhibitor-induced side effects in affected patients?
RCT (n=28)
Double-blind
Crossover
Does supplemental sodium acetate improve carbonic anhydrase inhibitor-induced side effects in affected patients?
Absolute Event Rate: 54% vs 18%
Supplemental sodium acetate (90 mEq/day) significantly improves carbonic anhydrase inhibitor-induced malaise and fatigue in approximately half of affected patients.
May ease CAI intolerance for half of affected patients; supports adjunctive use and extends tolerability data in glaucoma therapy.
A double-masked, randomly assigned, crossover trial of the effect of supplemental two-weak courses of sodium acetate (90 mEq/day) and placebo on carbonic anhydrase inhibitor (CAI)-induced side effects of malaise, fatigue, and others ("malaise symptom complex") was performed in 28 patients. Fifteen patients (54%) experienced significant improvement while receiving supplemental sodium acetate compared with five (18%) receiving a placebo. A relationship was observed between the clinical efficacy of the acetate supplementation and the measured improvement in serum carbon dioxide combining power. No changes in intraocular pressure were observed when supplemental sodium acetate was given. The results confirm the beneficial effect of supplemental alkalinization for such CAI-induced symptoms in somewhat less than half of the affected patients and suggest the need for long-term studies in which the dosage of sodium acetate is titrated in relation to measured changes in the level of metabolic acidosis.
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Arrigg et al. (1981) conducted an RCT in Carbonic anhydrase inhibitor (CAI)-induced side effects (n=28). Sodium acetate vs. Placebo was evaluated on Significant improvement in malaise symptom complex. Supplemental sodium acetate improved carbonic anhydrase inhibitor-induced malaise and fatigue in 54% of patients compared to 18% receiving placebo.
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