A Review on the Partial and Total Syntheses of Thiasteroids

This review describes the recent progceee achieved in the p a r t i a l and t o t a l wntheses of t h i a s t e r o i d s a s well a s i n t h e t o t a l syntheses of pyraeole and isoxazole analogues of steroids with sulfur atom in various positions of t h e s t s r o i d nucleus.There has been a tremendous progress i n recent years i n t h e f i e l d of thiaanalogues of aromatic and non-aronatio steroids.A voluminous l i t e r a t u r e on t h i a s t e r o i d s h a s appeared in recent times.I n s p i t e of the f a c t t h a t there appeared i n l i t e r a t u r e general reviews on and heterocyclic steroids1-11, a detailed account on t h e chemistry and syntheses of thias t e r o i d s of d i f f e r e n t types is not reported till date.This necessitated u s t o review and highlight t h e current trends achieved in t h e f i e l d or thiasteroids.POE the sake of convenience the review i s divided mainly i n t o two sections.Section 1.1 deals with the p a r t i a l and t o t a l ayntheses of thia-analogues of aromatic and non-aronatic s t e r o i d s while Section 1.2 concerns i t m l f nainly with the description of t h e t o t a l syntheses of pyrazole and isoxaeole analogues of s t e r o i d s with sulfur atom in 6, 7, 1 1 and l 2 + positions of the steroid nucleus.section 1.1 1-Thiasteroids: hhman and coworkers12, in 1968, achieved the t o t a l synthesis of 2-phenyl-A-+ steroid mmbering