Key result
Murine viral myocarditis models show myocardial fibrin deposition precedes fibrosis.
Why the study?
The pathogenesis of myocardial fibrosis in viral myocarditis that progresses to dilated cardiomyopathy is unknown.
Does fibrin deposition precede fibrosis in a murine model of viral myocarditis progressing to dilated cardiomyopathy?
Population
Inbred male C3H/He mice inoculated with coxsackievirus B3
Comparison
Time course of myocardial fibrin deposition and fibrosis after infection
Design
Preclinical experimental study
Follow-up
60 days
Authors
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No immediate clinical implications from murine model; leaves open whether targeting fibrin alters fibrosis progression in human viral myocarditis.
Does fibrin deposition precede fibrosis in a murine model of viral myocarditis progressing to dilated cardiomyopathy?
In a murine model of viral myocarditis, interstitial fibrin deposition precedes the development of myocardial fibrosis, suggesting a shared pathogenesis with healing wounds.
Schnitt et al. (1993) studied Viral myocarditis progressing to dilated cardiomyopathy. Coxsackievirus B3 infection was evaluated on Myocardial fibrin deposition and fibrosis. In a murine model of viral myocarditis, myocardial fibrin deposition appeared on day 3 and peaked at day 14, preceding myocardial fibrosis which was detectable at day 14 and maximal at day 60.
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