Key result
Spread-spectrum biosignal acquisition system achieves ~3% percentage root-mean-square difference for sinus rhythm and AF.
Why the study?
Multi-channel biosignal acquisition systems for ambulatory or invasive medical applications with high channel counts face challenges in reducing power consumption, area consumption, and outgoing wire count.
A novel spread-spectrum modulated biosignal acquisition system demonstrates efficient multi-channel recording of atrial electrograms with reduced power and area consumption.
May enable efficient preclinical multi-channel atrial recording; leaves open clinical translation and human validation.
The key challenges in designing a multi-channel biosignal acquisition system for an ambulatory or invasive medical application with a high channel count are reducing the power consumption, area consumption and the outgoing wire count. This paper proposes a spread-spectrum modulated biosignal acquisition system using a shared amplifier and an analog-to-digital converter (ADC). We propose a design method to optimize a recording system for a given application based on the required SNR performance, number of inputs, and area. The proposed method is tested and validated on real pre-recorded atrial electrograms and achieves an average percentage root- mean-square difference (PRD) performance of 2.65% and 3.02% for sinus rhythm (SR) and atrial fibrillation (AF), respectively by using pseudo-random binary-sequence (PRBS) codes with a code-length of 511, for 16 inputs. We implement a 4-input spread-spectrum analog front-end in a0.18 \,μ mCMOS process to demonstrate the proposed approach. The analog front-end consists of a shared amplifier, a2ⁿdorderΣ ΔADC sampled at7.8 \,MHz, used for digitization, and an on-chip 7-bit PRBS generator. It achieves a number-of-inputs to outgoing-wire ratio of 4:1 while consuming23 \,μ A/input including biasing from a1.8 \,Vpower supply and0.067 \,mm²in area.
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Rout et al. (2023) studied Atrial fibrillation and sinus rhythm (Atrial electrograms) (n=16). Spread-spectrum modulated biosignal acquisition system using a shared analog CMOS front-end vs. Original unmodulated signal was evaluated on Percentage root-mean-square difference (PRD) performance. The proposed spread-spectrum modulated biosignal acquisition system achieved an average percentage root-mean-square difference of 2.65% for sinus rhythm and 3.02% for atrial fibrillation using 16 inputs.
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