Why the study?
To investigate the common key targets and signaling pathways of Notoginseng Radix et Rhizoma in the protection against diabetic nephropathy, diabetic encephalopathy, and diabetic cardiomyopathy.
Population
166 chemical components and 835 component targets of Notoginseng Radix et Rhizoma, and disease targets of DN, DE, and DCM
Design
Network pharmacology and bioinformatics study
Key result
Notoginseng Radix et Rhizoma potentially protects against diabetic nephropathy, encephalopathy, and cardiomyopathy by regulating the AGE-RAGE and FoxO pathways and 7 common targets including STAT3.
Authors
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Hypothesis-generating for Notoginseng in diabetic cardiomyopathy; leaves open clinical translation and requires prospective trials.
This network pharmacology study identifies potential molecular targets and pathways by which Notoginseng Radix et Rhizoma may exert protective effects against diabetic complications including cardiomyopathy.
Xiang et al. (2021) studied Diabetic nephropathy, diabetic encephalopathy, and diabetic cardiomyopathy. Notoginseng Radix et Rhizoma was evaluated on Common key targets and signaling pathways. Notoginseng Radix et Rhizoma potentially protects against diabetic nephropathy, encephalopathy, and cardiomyopathy by regulating the AGE-RAGE and FoxO pathways and 7 common targets including STAT3.