Why the study?
Although ginseng has a role in diabetes mellitus management, the specific ginsenosides involved are not systematically defined and their targets remain incomplete.
Design
Network pharmacology and molecular docking study
Key result
Network pharmacology and molecular docking revealed that 28 ginsenosides from ginseng may manage diabetes mellitus by stably binding to core targets such as mTOR, IL-1β, and TNF-α.
Authors
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Hypothesis-generating for ginsenoside targets in diabetes; leaves open clinical translation pending validation.
Network pharmacology and molecular docking suggest that specific ginsenosides may manage diabetes mellitus by targeting key proteins like VEGFA and modulating insulin and AMPK signaling pathways.
Li et al. (2023) studied Diabetes mellitus. Ginsenosides was evaluated on Binding energy and stability of ginsenosides with core targets. Network pharmacology and molecular docking revealed that 28 ginsenosides from ginseng may manage diabetes mellitus by stably binding to core targets such as mTOR, IL-1β, and TNF-α.
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