Key result
28 ginseng ginsenosides may manage diabetes by stably binding to targets like mTOR and TNF-α.
Why the study?
Although ginseng has a role in diabetes mellitus management, the specific ginsenosides involved are not systematically defined and their targets remain incomplete.
Network pharmacology and molecular docking suggest that specific ginsenosides may manage diabetes mellitus by targeting key proteins like VEGFA and modulating insulin and AMPK signaling pathways.
Answers are grounded in this paper and cite their sources.
Hypothesis-generating for ginsenoside targets in diabetes; leaves open clinical translation pending validation.
A large body of literature has shown that ginseng had a role in diabetes mellitus management. Ginsenosides are the main active components of ginseng. But what ginsenosides can manage in diabetic are not systematic. The targets of these ginsenosides are still incomplete. Our aim was to identify which ginsenosides can manage diabetes mellitus through network pharmacology and molecular docking. To identify the targets of these ginsenosides. In this work, we retrieved and screened ginsenosides and corresponding diabetes mellitus targets across multiple databases. PPI networks of the genes were constructed using STRING, and the core targets were screened out through topological analysis. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analyses were performed by using the R language. Finally, molecular docking was performed after bioinformatics analysis for verification. Our research results showed that 28 ginsenosides in ginseng might be against diabetes mellitus by modulating related proteins such as VEGFA, Caspase 3, and TNF-α. Among the 28 ginsenosides, 20(R)-Protopanaxatriol, 20(R)-Protopanaxadiol, and Ginsenoside Rg1 might play a significant role. Kyoto Encyclopedia of Genes and Genomes and Gene Ontology enrichment analysis showed that the management of diabetes mellitus by ginsenosides may be related to the positive regulation of reactive oxygen metabolic processes, associated with the insulin signaling pathway, TNF signaling pathway, and AMPK signaling pathway. Molecular docking results and molecular dynamics simulation showed that most ginsenosides could stably bind to the core target, mainly hydrogen bonding and hydrophobic bond. This study suggests the management of ginseng on diabetes mellitus. We believe that our results can contribute to the systematic study of the mechanism of ginsenosides for the management of diabetes mellitus. At the same time, it can provide a theoretical basis for subsequent studies on the management of ginsenosides in diabetes mellitus.
No takes yet. Share an insight, caveat, or question.
Li et al. (2023) studied Diabetes mellitus. Ginsenosides was evaluated on Binding energy and stability of ginsenosides with core targets. Network pharmacology and molecular docking revealed that 28 ginsenosides from ginseng may manage diabetes mellitus by stably binding to core targets such as mTOR, IL-1β, and TNF-α.
Synapse has enriched 10 related papers. Consider them for comparative context: