Key result
Sepsis survivorship is linked to increasing rates of depression and cognitive decline.
Why the study?
While sepsis survival has improved, the incidence of sepsis-related neuropsychiatric disorders like depression is increasing, highlighting the need to understand underlying pathophysiologic mechanisms to develop effective treatments.
This review highlights the increasing incidence of sepsis-induced depression and the need to elucidate its pathophysiologic mechanisms for developing effective treatments.
Progress in medicine such as the use of anti-infective drugs and development of the advanced life support equipment has greatly improved the survival rate of patients with sepsis. However, the incidence of sepsis-related diseases is increasing. These include severe neurologic and psychologic disorders, cognitive decline, anxiety, depression, and post-traumatic stress disorder. Cerebral dysfunction occurs via multiple interacting mechanisms, with different causative pathogens having distinct effects. Because sepsis-related diseases place a substantial burden on patients and their families, it is important to elucidate the underlying pathophysiologic mechanisms to develop effective treatments.
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Wang et al. (2023) conducted a review in Sepsis-induced depression. Sepsis-related diseases, including depression and cognitive decline, are increasing among survivors, highlighting the need to elucidate underlying pathophysiologic mechanisms to develop treatments.
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