Key result
Proactive amlodipine/atorvastatin therapy lowers calculated 10-year CHD risk by ~23% versus usual care.
Why the study?
Does a proactive multifactorial risk factor intervention strategy using single-pill amlodipine/atorvastatin reduce calculated Framingham 10-year CHD risk compared with usual care in hypertensive patients with additional risk factors?
RCT (n=1,461)
open-label
cluster randomized
Yes
Does a proactive multifactorial risk factor intervention strategy using single-pill amlodipine/atorvastatin reduce calculated Framingham 10-year CHD risk compared with usual care in hypertensive patients with additional risk factors?
Absolute Event Rate: 12.5% vs 16.3%
p-value: p=< 0.001
A proactive multifactorial intervention using single-pill amlodipine/atorvastatin significantly reduced calculated 10-year CHD risk compared to usual care in hypertensive patients with multiple risk factors.
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Supports proactive single-pill amlodipine/atorvastatin in high-risk hypertensives; extends RCT evidence for multifactorial risk reduction versus usual care.
Zamorano et al. (2011) conducted an RCT in hypertension and additional cardiovascular risk factors (n=1,461). proactive multifactorial risk factor intervention strategy using single-pill amlodipine/atorvastatin vs. usual care was evaluated on calculated Framingham 10-year CHD risk at 52 weeks (p=< 0.001). A proactive multifactorial risk factor intervention using amlodipine/atorvastatin significantly reduced calculated Framingham 10-year CHD risk compared with usual care (12.5% vs 16.3%; P<0.001).
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