Key result
Higher BMI strongly correlates with elevated Endothelin-1, linking obesity to endothelial dysfunction and oxidative stress.
Why the study?
Endothelial dysfunction and oxidative stress are linked to obesity, but their correlation in apparently healthy obese men was not established.
Cross-Sectional (n=80)
No
Endothelial dysfunction (measured by Endothelin-1) and oxidative stress (measured by malondialdehyde) are positively correlated with each other and with BMI in apparently healthy men.
These associations in healthy men are hypothesis-generating; prospective studies needed before assessing cardiovascular risk or interventions.
Background and objective: Obesity is the risk for many disease conditions and is becoming a global issue. Endothelial dysfunction and oxidative stress are linked to obesity. Endothelin-1 is a useful marker of endothelial dysfunction. Oxidative stress can be assessed by estimation of lipid peroxidation byproduct malondialdehyde. In this study, we tried to find out the correlation between Endothelin-1 and oxidative stress among apparently healthy obese men. Methods: Eighty apparently healthy non-smoker adult men have participated in this study. Their age ranged between 18 and 50 years. Their serum Endothelin-1 (ELISA), malondialdehyde and lipid parameters (biochemical assays) have been estimated. Results: Subjects were divided into three groups: normal weight (n = 25), overweight (n = 34) and obese (n = 26) basing on their body mass index. The study shows that Endothelin-1 is significantly correlated with each of Malondialdehyde and body mass index (r = 0.262, P = 0.019; r = 0.65, P <0.001 respectively). Malondialdehyde is also significantly positively correlated with BMI (r = 0.378, P = 0.001). Conclusion: Endothelial dysfunction and oxidative stress coexist in obesity. But which of them precedes the other? Is still a question needs to be further studied
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Ahmed et al. (2016) conducted a cross-sectional in Obesity (n=80). Obesity (elevated BMI) vs. Normal weight was evaluated on Correlation between Endothelin-1 and body mass index (r = 0.65, p=<0.001). Body mass index was significantly positively correlated with serum Endothelin-1 (r = 0.65) and malondialdehyde (r = 0.378) in apparently healthy men, suggesting endothelial dysfunction and oxidative stress coexist in obesity.
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