Key result
Elevated hs-CRP shows no association with dyslipidemia or lipid parameters in T2DM.
Why the study?
With rising type 2 diabetes mellitus prevalence in Nigeria, more comprehensive cardiovascular risk prediction tools incorporating both traditional and newer biomarkers like high-sensitivity C-reactive protein are needed.
Is there an association between elevated hs-CRP levels and dyslipidaemia in Nigerian patients with T2DM?
Cross-Sectional (n=300)
No
Is there an association between elevated hs-CRP levels and dyslipidaemia in Nigerian patients with T2DM?
Absolute Event Rate: 179.1% vs 186.2%
p-value: p=0.408
In Nigerian patients with T2DM, hs-CRP levels are significantly elevated compared to controls but do not correlate directly with lipid parameters, suggesting inflammation contributes to cardiovascular risk via non-lipid pathways.
Elevated hs-CRP in Nigerian T2DM patients may signal CVD risk via non-lipid pathways; leaves open its incremental value for risk prediction.
BACKGROUND: Cardiovascular disease (CVD) is a leading cause of morbidity and mortality among individuals with type 2 diabetes mellitus (T2DM). Inflammation, marked by elevated high-sensitivity C-reactive protein (hs-CRP) levels, and dyslipidaemia, are critical contributors to atherosclerosis and cardiovascular risk. In Nigeria, where T2DM prevalence is rising, there is a need for more comprehensive risk prediction tools, incorporating both traditional and newer biomarkers such as hs-CRP. This study aimed to investigate the association between elevated hs-CRP levels and dyslipidaemia in Nigerian patients with T2DM and to explore the potential implications for cardiovascular risk prediction. METHODS: A hospital-based cross-sectional study was conducted among 150 T2DM patients and 150 age-matched controls. Data on socio-demographics, medical history, clinical characteristics, and laboratory parameters, including lipid profiles and hs-CRP levels, were collected. The relationship between hs-CRP levels and lipid parameters was assessed using Pearson's correlation coefficient and independent t-tests. RESULTS: T2DM patients exhibited significantly higher hs-CRP levels (2.2 ± 1.8 mg/L vs. 1.2 ± 1.0 mg/L, p < 0.001), dyslipidaemia (p < 0.001), and blood pressure (SPB- 127.6 ± 12.4 mmHg, DBP- 77.6 ± 6.6 mmHg vs. SBP- 119.6 ± 10.8 mmHg, DBP- 72.1 ± 8.0 mmHg; p = 0.001) compared to controls. However, no significant correlation was found between hs-CRP levels and lipid parameters. CONCLUSION: Although no direct association was found between elevated hs-CRP levels and dyslipidaemia, hs-CRP remains an important marker of cardiovascular risk possibly through non-lipid pathways, such as inflammation-driven endothelial dysfunction. Further research is needed to evaluate its potential role in refining cardiovascular risk assessment in the Nigerian T2DM population. CLINICAL TRIAL NUMBER: Not applicable.
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Mohammed et al. (2025) conducted a cross-sectional in Type 2 diabetes mellitus (n=300). Elevated high-sensitivity C-reactive protein (> 3 mg/L) vs. Normal hs-CRP (< 3 mg/L) was evaluated on Total cholesterol levels (mg/dL) (p=0.408). In Nigerian patients with type 2 diabetes, elevated hs-CRP levels were not significantly associated with dyslipidaemia, showing no correlation with total cholesterol, triglycerides, LDL, or HDL.
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