Key result
Low-dose ketamine with diazepam premedication achieves ~97% satisfactory MRI sedation in children with rare laryngospasm.
Why the study?
The authors aimed to describe the use of low doses of ketamine hydrochloride with diazepam premedication to sedate children undergoing MRI in an environment without an MRI-compatible anaesthetic machine.
Can low doses of ketamine and diazepam safely and effectively sedate children undergoing MRI in a resource-poor setting?
Observational (n=60)
Yes
Can low doses of ketamine and diazepam safely and effectively sedate children undergoing MRI in a resource-poor setting?
Low-dose ketamine with diazepam premedication provides safe and effective sedation for children undergoing MRI in resource-limited settings without MRI-compatible anesthetic machines.
Successful low-dose ketamine-diazepam sedation enabled pediatric MRI without specialized equipment; hypothesis-generating and requires prospective validation before wider use.
We aimed to describe the successful use of low doses of ketamine hydrochloride with diazepam premedication to sedate children with ages between 3days to five years who presented at three diagnostic centres in Port Harcourt Nigeria for magnetic resonance imaging (MRI) within a five-year period. This was done in an environment with no MRI compatible anaesthetic machine and monitoring was done by the anaesthetist within the suites. The average age of the children was ten months with a mean dose of 18mg of ketamine used. The mean duration of the procedures was 44.92 minutes and constant presence of the anaesthetist was required throughout the procedures for monitoring. Two incidences of self-limiting laryngospasm occurred with a safe outcome for all of the patients. Children can be satisfactorily sedated with low doses of ketamine for MRI in some less than ideal situations.
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Otokwala et al. (2021) conducted an observational in Children requiring sedation for MRI (n=60). Low doses of ketamine and diazepam was evaluated on Satisfactory outcome of sedation. Low doses of ketamine with diazepam premedication provided satisfactory sedation for MRI in 96.7% of children in a resource-limited setting, with only two cases of self-limiting laryngospasm.
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