Key result
Dobutamine infusion in septic shock is linked to a ~36% increase in cardiac index.
Why the study?
The hemodynamic effects of dobutamine infusion in patients with septic shock were studied to evaluate its potential benefits and adverse effects.
Does dobutamine infusion improve hemodynamic parameters in patients with septic shock?
Population
19 patients with septic shock
Comparison
Dobutamine infusion vs baseline hemodynamics
Design
Observational study
Authors
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Supports dobutamine for acute hemodynamic gains in septic shock; hypothesis-generating and should not yet change practice.
Observational (n=19)
Does dobutamine infusion improve hemodynamic parameters in patients with septic shock?
Effect estimate: +36%
p-value: p=<0.001
Dobutamine infusion improves hemodynamics in septic shock by increasing cardiac and stroke indices, and is particularly useful when filling pressures are high due to fluid overload or cardiac failure.
Jardin et al. (1981) conducted an observational in septic shock (n=19). Dobutamine infusion was evaluated on cardiac index (+36%, p=<0.001). Dobutamine infusion in patients with septic shock significantly increased cardiac index (+36%, p<0.001), stroke index (+15%, p<0.01), and mean arterial pressure (+20%, p<0.01).
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