Why the study?
EndoPAT-derived reactive hyperemia index (RHI) assesses peripheral endothelial dysfunction, but its clinical value after acute ischemic stroke remains uncertain.
Is low peripheral endothelial function (RHI ≤1.67) associated with worse functional outcomes and clinical events in patients with acute ischemic stroke?
Population
357 acute ischemic stroke patients with valid RHI measurements
Comparison
Low RHI (≤1.67) vs normal RHI
Design
Retrospective analysis of a prospectively maintained single-center registry
Follow-up
3 months
Key result
Low pre-discharge reactive hyperemia index (≤1.67) was associated with poor discharge functional outcome after acute ischemic stroke (adjusted OR 1.82; 95% CI 1.04-3.18; P=0.036).
Authors
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Low RHI may flag higher short-term risk after ischemic stroke; leaves open independent prognostic value beyond discharge.
Cohort (n=357)
No
Is low peripheral endothelial function (RHI ≤1.67) associated with worse functional outcomes and clinical events in patients with acute ischemic stroke?
Odds Ratio: 1.82 (95% CI 1.04–3.18)
Absolute Event Rate: 32.9% vs 25%
p-value: p=0.036
Low pre-discharge reactive hyperemia index is associated with poor functional outcome at discharge but lacks independent prognostic value for longer-term outcomes or clinical events after acute ischemic stroke.
Kim et al. (2026) conducted a cohort in Acute ischemic stroke (n=357). Low reactive hyperemia index (RHI ≤1.67) vs. Normal reactive hyperemia index was evaluated on Poor discharge functional outcome (adjusted OR 1.82, 95% CI 1.04-3.18, p=0.036). Low pre-discharge reactive hyperemia index (≤1.67) was associated with poor discharge functional outcome after acute ischemic stroke (adjusted OR 1.82; 95% CI 1.04-3.18; P=0.036).
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