Key result
Ketosis-onset diabetes is linked to ~248% higher odds of lower limb atherosclerotic plaque versus controls.
Why the study?
The clinical features of atherosclerotic lesions in ketosis-onset diabetes were largely absent and needed comparison with type 1 and non-ketotic type 2 diabetes.
Comparison
Ketosis-onset diabetes vs type 1 diabetes vs non-ketotic type 2 diabetes vs controls
Design
Cross-sectional study
Authors
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May warrant closer lower limb atherosclerosis monitoring in ketosis-onset diabetes; leaves open whether subtype-specific screening is needed.
Cross-Sectional (n=538)
No
Odds Ratio: 3.48 (95% CI 1.38–8.77)
Absolute Event Rate: 47.6% vs 25.8%
p-value: p=0.013
Ketosis-onset diabetes exhibits lower limb atherosclerotic lesion characteristics and risk factors similar to non-ketotic type 2 diabetes, supporting its classification as a subtype of type 2 diabetes.
Li et al. (2014) conducted a cross-sectional in Newly diagnosed diabetes (ketosis-onset, type 1, non-ketotic type 2) (n=538). Ketosis-onset diabetes vs. Control subjects without diabetes was evaluated on Prevalence of lower limb atherosclerotic plaque (OR 3.48, 95% CI 1.38-8.77, p=0.013). Ketosis-onset diabetes was associated with a significantly higher prevalence of lower limb atherosclerotic plaque compared to control subjects without diabetes (47.6% vs 25.8%, OR 3.48).
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