Key result
Tocolytic nifedipine use for preterm labor is linked to AF in a pregnant patient.
Why the study?
Calcium channel blockers are commonly used as tocolytic agents but rare cardiovascular complications such as atrial fibrillation have been reported.
Does nifedipine use as a tocolytic agent cause atrial fibrillation in pregnant women with threatened preterm labor?
Case Report (n=1)
Does nifedipine use as a tocolytic agent cause atrial fibrillation in pregnant women with threatened preterm labor?
Nifedipine, commonly used as a tocolytic agent, may rarely cause atrial fibrillation, which can have significant consequences for both mother and fetus.
Nifedipine tocolysis may trigger AF in pregnancy; single case leaves causal link and surveillance needs open.
Calcium channel blockers are commonly used tocolytic agents on Labor and Delivery units worldwide as part of the management of preterm labor. Despite their overall reassuring safety profile, rare cardiovascular complications have been reported. In this report, we describe the case of threatened preterm labor managed with nifedipine with subsequent development of atrial fibrillation. This type of cardiac arrhythmia may have considerable consequences for both the mother and the fetus. The aim of this case report and comprehensive review of the literature is to raise awareness.
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Docheva et al. (2018) conducted a case report in Threatened preterm labor (n=1). Nifedipine was evaluated on Atrial fibrillation. Nifedipine use as a tocolytic agent for threatened preterm labor was associated with the development of atrial fibrillation in a pregnant patient.
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