Key result
CytoSorb hemoperfusion plus CRRT accelerates quetiapine elimination and stabilizes a patient following severe overdose.
Why the study?
Extracorporeal techniques for quetiapine removal might be helpful in overdose, but only a few cases have been reported in the literature.
Case Report (n=1)
CytoSorb hemoperfusion combined with CRRT may be a feasible approach for rapid drug removal and stabilization in severe quetiapine overdose.
May support CytoSorb-CRRT as rescue in severe quetiapine overdose; hypothesis-generating and should not yet change practice.
Quetiapine overdose, although rare, is mainly linked with tachycardia, QTc-interval prolongation, somnolence, coma, hyperglycemia, and eventually hepatotoxicity and myocarditis. Extracorporeal techniques for quetiapine removal might be helpful, but only a few cases are reported in the literature. We here describe the case of a 27-year-old healthy woman, admitted to our Intensive Care Unit after voluntary quetiapine intake and successfully treated with CytoSorb hemoperfusion in combination with continuous renal replacement therapy (CRRT), in order to accelerate quetiapine elimination. This is the first published experience about the potential application of hemoadsorption therapies, as CytoSorb sorbent, in large overdoses of quetiapine and this approach might be feasible to rapidly remove the substance from blood, stabilizing the patient condition.
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Giuntoli et al. (2019) conducted a case report in Severe quetiapine voluntary overdose (n=1). CytoSorb hemoperfusion in combination with continuous renal replacement therapy (CRRT) was evaluated on Patient stabilization and quetiapine elimination. CytoSorb hemoperfusion combined with continuous renal replacement therapy successfully accelerated quetiapine elimination and stabilized a patient following a severe voluntary overdose.
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