Key result
Clopidogrel is well tolerated in pediatric AIS but linked to ~12% subdural hematomas with aspirin.
Why the study?
The possible risks and safety of clopidogrel in children with arterial ischemic stroke have not been assessed.
Is clopidogrel safe and well-tolerated in children with arterial ischemic stroke?
Cohort (n=17)
Is clopidogrel safe and well-tolerated in children with arterial ischemic stroke?
Clopidogrel is relatively well tolerated in pediatric arterial ischemic stroke, but combination with aspirin may increase the risk of intracranial bleeding.
Clopidogrel may be tolerable in pediatric arterial ischemic stroke; leaves open bleeding risk with aspirin pending larger prospective data.
BACKGROUND AND PURPOSE: The purpose of this study was to determine safety and tolerability of clopidogrel in children with arterial ischemic stroke (AIS). Clopidogrel is the alternative antiplatelet medication when aspirin is not tolerated or fails. The possible risks and safety of clopidogrel in children with AIS have not been assessed. METHODS: This is a prospective consecutive cohort study of children with AIS who were started on clopidogrel. Seventeen children were included. RESULTS: Two children developed subdural hematomas while on clopidogrel in conjunction with aspirin. Two others had headache or hand numbness. No other side effects like rash or gastrointestinal upsets were reported. CONCLUSIONS: We found clopidogrel to be relatively well tolerated in the pediatric population. In combination with aspirin and in the presence of other risk factors, intracranial bleeding may be seen.
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Soman et al. (2006) conducted a cohort in Arterial ischemic stroke (AIS) (n=17). Clopidogrel was evaluated on Safety and tolerability. Clopidogrel was relatively well tolerated in children with arterial ischemic stroke, though 2 of 17 patients (11.8%) developed subdural hematomas when used in conjunction with aspirin.
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