Why the study?
Does clopidogrel achieve adequate platelet inhibition in infants and young children with cardiac conditions at risk for arterial thrombosis?
Population
92 randomized children with a cardiac condition at risk for arterial thrombosis. 79% of randomized and…
Comparison
Clopidogrel for ≥7 and ≤28 days vs Placebo
Design
RCT, 3:1 ratio in 4 sequential groups, placebo-controlled
Follow-up
≥7 and ≤28 days
Authors
Loading...
Supports clopidogrel 0.20 mg/kg/d in infants and young children at thrombosis risk; extends adult platelet inhibition data to this pediatric population.
Does clopidogrel achieve adequate platelet inhibition in infants and young children with cardiac conditions at risk for arterial thrombosis?
Clopidogrel at a dose of 0.20 mg/kg/day achieves adequate platelet inhibition in infants and young children, comparable to adult dosing, without causing serious bleeding.
Li et al. (2008) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: