Loading, Pretreatment, and Interindividual Variability Issues With Clopidogrel Dosing
Key result
Clopidogrel loading and maintenance doses in ACS and PCI only recently undergo active investigation.
Why the study?
Investigations into the optimal loading and maintenance doses of clopidogrel have only recently been pursued despite its widespread use.
Design
Review
Authors
Discussion
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Member takes
Implication
Clopidogrel's CYP3A4-dependent activation may alter antiplatelet response with interacting drugs; leaves open need for interaction trials before practice change.
Structured PICO
I
Intervention
Clopidogrel
Provides a historical overview of clopidogrel dosing and highlights the need for further investigation into optimal loading and maintenance strategies.
Cite This Study
Bates et al. (2005) reported a review. Clopidogrel was evaluated. Investigations into the optimal loading and maintenance doses of clopidogrel have only recently been pursued despite its widespread use in acute coronary syndromes and percutaneous coronary intervention.