What question did this study set out to answer?

To compare oncological outcomes and patterns of recurrence according to lymphovascular space invasion status, and to identify independent preoperative predictors of invasion in early-stage endometrioid endometrial cancer.

May 4, 2023CancersOpen Access

Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group

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Authors

RPReyes Oliver PérezUniversidad Complutense de Madrid PPPablo Padilla-IserteUniversitat de València OAOctavio ArencibiaHospital Materno-Infantil

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Implication

Retrospective cohort study reveals that lymphovascular space invasion increases distant recurrence risk in early-stage endometrial cancer, highlighting the need for risk-adapted management.

Key Points

To compare oncological outcomes and patterns of recurrence according to lymphovascular space invasion status, and to identify independent preoperative predictors of invasion in early-stage endometrioid endometrial cancer.
Conducted a multicenter retrospective cohort study across centers in Spain evaluating 3,546 women with postoperative early-stage (FIGO I-II, 2009) endometrioid endometrial cancer.
Evaluated disease-free survival (DFS), overall survival (OS), and recurrence patterns using Cox proportional hazard models, along with univariate and multivariate logistic regression to identify predictors.
Positive lymphovascular space invasion (LVSI) was identified in 528 patients (14.6%) and served as an independent predictor of worse DFS (HR 1.8), worse OS (HR 2.1), and distant recurrence (HR 2.37).
Distant recurrences occurred in 78.2% of LVSI-positive patients compared with 61.3% of LVSI-negative patients (p < 0.01).
Independent predictors of LVSI were deep myometrial invasion (OR 3.04), high-grade tumors (OR 2.54), tumor diameter ≥ 2 cm (OR 2.03), and cervical stroma invasion (OR 2.01).

Cite This Study

Pérez et al. (2023) studied this question.

synapsesocial.com/papers/6aa94e715349ab3cd2263f96 https://doi.org/10.3390/cancers15092612

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Implication

Retrospective cohort study reveals that lymphovascular space invasion increases distant recurrence risk in early-stage endometrial cancer, highlighting the need for risk-adapted management.

Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group

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Key Points

Cite This Study

Lymphovascular Space Invasion in Early-Stage Endometrial Cancer (LySEC): Patterns of Recurrence and Predictors. A Multicentre Retrospective Cohort Study of the Spain Gynecologic Oncology Group

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