Key result
Statins upregulate endothelial thrombomodulin via NO-dependent HSF1 dissociation and TM promoter binding.
Authors
Loading...
No immediate change to statin use; extends mechanistic understanding of endothelial effects.
Fu et al. (2008) studied this question. Statins was evaluated on Transcriptional upregulation of endothelial thrombomodulin. Statins upregulate endothelial thrombomodulin via a mechanism involving NO-dependent dissociation of HSF1 from heat shock protein 90, nuclear translocation, and binding to the TM promoter.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: