Key result
Tight BP control lowers mean dBP by ~4 mmHg versus less tight control.
Why the study?
It was uncertain whether less tight versus tight control of nonsevere hypertension in pregnancy results in different diastolic blood pressure and clinical outcomes.
Does less tight blood pressure control compared to tight control affect mean diastolic blood pressure in pregnant women with nonsevere hypertension?
Population
132 pregnant women with nonsevere hypertension at 20-33(+6) weeks gestation
Comparison
Less tight control (target dBP 100 mmHg) vs tight control (target dBP 85 mmHg)
Follow-up
Up to 36 weeks gestation
Authors
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Tight control lowers diastolic BP in nonsevere gestational hypertension; confirms randomization feasibility for definitive maternal-perinatal outcome trials.
RCT (n=132)
Randomised
Yes
Does less tight blood pressure control compared to tight control affect mean diastolic blood pressure in pregnant women with nonsevere hypertension?
Mean Difference: -3.5 (95% CI -6.4–-0.6)
This pilot trial confirms the feasibility of randomizing pregnant women with nonsevere hypertension to different blood pressure targets, paving the way for a definitive trial on maternal and perinatal outcomes.
Magee et al. (2007) conducted an RCT in Nonsevere hypertension in pregnancy (n=132). Less tight blood pressure control vs. Tight blood pressure control (target dBP 85 mmHg) was evaluated on Mean dBP at 28, 32 and 36 weeks (MD -3.5 mmHg, 95% CI -6.4 to -0.6). Tight blood pressure control (target dBP 85 mmHg) significantly lowered mean diastolic blood pressure by 3.5 mmHg (95% CI -6.4 to -0.6) compared to less tight control (target dBP 100 mmHg).
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