Key result
Resting state fNIRS functional connectivity helps classify mental disorder patients from healthy controls.
Why the study?
This study aims to apply affective computing to mental disorders to classify healthy people and those with mental illnesses.
Can resting state fNIRS functional connectivity analysis classify patients with mental disorders versus healthy controls?
Cross-Sectional (n=85)
Can resting state fNIRS functional connectivity analysis classify patients with mental disorders versus healthy controls?
Resting state fNIRS combined with functional connectivity analysis may provide a method for detecting and identifying mental disorders.
May support fNIRS connectivity for mental disorder classification; hypothesis-generating and requires prospective validation before clinical adoption.
Affective computing is important for making computers smarter. When emotion can be quantified, machines can understand it. This study aims to apply affective computing to mental disorders, and to classify healthy people and mentally illnesses. For this purpose, 85 subjects, including major depressive disorder patients, schizophrenia patients, and health control people were recruited to participate in resting state functional near infrared spectroscopy (fNIRS) experiment. We measured the changes in oxygenated blood concentration in the prefrontal cortex (PFC). We then used three types of correlation analysis methods to construct the functional connectivity matrices: Pearson correlation analysis (CORR), amplitude squared coherence coefficient (COH), and phase locking value (PLV). We performed the small-world model and centrality analysis based on these matrices. The results demonstrated the existence of a small-world model in both patients and healthy people’s brain networks. Furthermore, features such as the characteristic path length and betweenness centrality extracted from the functional connectivity matrix are helpful for classifying patients and healthy people, thus providing a method for detecting and identifying mental disorders.
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Wu et al. (2020) conducted a cross-sectional in Major depressive disorder and schizophrenia (n=85). Resting state fNIRS functional connectivity features vs. Healthy controls was evaluated on Classification of patients and healthy people. Resting state fNIRS functional connectivity features, such as characteristic path length and betweenness centrality, were helpful for classifying mental disorder patients and healthy controls.
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