What question did this study set out to answer?

To determine the oral toxicity and resulting pathological changes of ingesting the cyanobacterium Cylindrospermopsis raciborskii and its associated toxin in mice.

February 1, 1999Environmental Toxicology

The oral toxicity for mice of the tropical cyanobacteriumCylindrospermopsis raciborskii (Woloszynska)

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To determine the oral toxicity and resulting pathological changes of ingesting the cyanobacterium Cylindrospermopsis raciborskii and its associated toxin in mice.
Fasted male outbred MF1 mice received a single oral gavage of freeze-dried C. raciborskii culture containing 0.2% cylindrospermopsin suspended in normal saline.
Mice were monitored for mortality to determine the median lethal dose and underwent postmortem histopathological evaluations of internal organs.
The median lethal dose was between 4.4 and 6.9 mg/kg alkaloid equivalent, with fatalities occurring between 2 and 6 days post-administration.
Pathology revealed severe liver damage marked by fatty change and periacinar coagulative necrosis, acute renal tubular necrosis, thymic and splenic lymphoid atrophy, heart hemorrhages, and gastric mucosal ulcerations.

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Implication

Experimental study reveals significant oral toxicity and multi-organ damage from Cylindrospermopsis raciborskii in mice, highlighting risks associated with contaminated drinking water.

Cite This Study

Seawright et al. (1999) studied this question.

synapsesocial.com/papers/6aa959bd11a60bccbd26520a https://doi.org/10.1002/(sici)1522-7278(199902)14:1<135::aid-tox17>3.0.co;2-l

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Implication

Experimental study reveals significant oral toxicity and multi-organ damage from Cylindrospermopsis raciborskii in mice, highlighting risks associated with contaminated drinking water.

The oral toxicity for mice of the tropical cyanobacteriumCylindrospermopsis raciborskii (Woloszynska)

Key Points

Discussion

Implication

Cite This Study

The oral toxicity for mice of the tropical cyanobacteriumCylindrospermopsis raciborskii (Woloszynska)

Key Points

Discussion

Implication

Cite This Study

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